Plakophilins, desmogleins, and pemphigus: the tail wagging the dog
نویسندگان
چکیده
The importance of desmosomal cell adhesion to human health is evidenced by the autoimmune disease pemphigus vulgaris (PV), in which autoantibodies against the extracellular domain of the desmosomal cadherin desmoglein 3 cause potentially fatal blistering of the skin and mucous membranes. Tucker et al. describe how enhanced expression of a desmosomal cytoplasmic plaque protein, plakophilin-1, protects keratinocytes from PV IgG-induced loss of cell adhesion by inducing calcium-independent hyperadhesive desmosomes. This study beautifully demonstrates that desmosomal adhesion can be modulated by the molecular interactions of the desmoglein tail and suggests that these novel regulatory pathways may possibly be exploited in treating human disease.
منابع مشابه
The desmosome.
Desmosomes are intercellular junctions that tether intermediate filaments to the plasma membrane. Desmogleins and desmocollins, members of the cadherin superfamily, mediate adhesion at desmosomes. Cytoplasmic components of the desmosome associate with the desmosomal cadherin tails through a series of protein interactions, which serve to recruit intermediate filaments to sites of desmosome assem...
متن کاملBehavioural responses of Canis familiaris to different tail lengths of a remotely-controlled life-size
The tail of dogs and allies (Canidae) is important for intraspecific communication. We used a life-sized dog model and varied the tail length and motion as an experimental method of examining effects of tail-docking on intraspecific signaling in domestic dogs, Canis familiaris. We videotaped interactions of 492 off-leash dogs and quantified size and behaviour of approaching dogs to the model’s ...
متن کاملPemphigus erythematosus and cutaneous epitheliotropic lymphoma in a Labrador Retriever dog
Background: Paraneoplastic pemphigus is an autoimmune blistering skin disease associated with concurrent neoplasia that is rarely observed in veterinary medicine. Case description: This case report presents a ten-year-old female Labrador Retriever dog with generalized seborrhea and alopecic, crusting and ulcerative lesions in the periocular and perioral regions...
متن کامل